You may be eligible to exclude 250,000 of the gain (500,000) if Married Filing Jointly if you owned and lived in the home 2 of the last 5 years.
The exclusion can only be taken once every two years.
TurboTax will walk you through the process.
There was a time where capital gains on personal homes could be deferred if a home of equal or greater value was purchased, but that is no longer the case.
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